Vitamin B6

Vitamin B6 is a water-soluble member of the Vitamin-B Complex, which has three forms: pyridoxal, pyridoxine, pyridoxamine. Pyridoxal 5'-phosphate (“PLP”) is the primary coenzyme form and is important in human metabolism.[1-3]

PLP plays a vital role in the function of approximately 100 enzymes that catalyze essential chemical reactions in the human body.[1-5] PLP is involved in the metabolism of amino acids, carbohydrates, and lipids.[5]

The synthesis of the neurotransmitter serotonin is catalyzed by a PLP-dependent enzyme. Other neurotransmitters, such as dopamine, norepinephrine and gamma-aminobutyric acid (“GABA”), are also synthesized using PLP-dependent enzymes.[4]

A study of healthy elderly men found Vitamin B6 supplementation improved memory but had no effect on mood or mental performance.[6]

A trial involving healthy young, middle-aged, and older women found Vitamin B6 supplementation improved memory performance in some age groups but had no effect on mood.[7]

Reduced production of immune system constituents lymphocytes and interleukin-2 have been reported in Vitamin B6 deficient individuals.[6]

Each serving of Elebra contains Vitamin B6, and is manufactured in the USA at a cGMP facility that has an "A" rating (the highest possible) from the National Nutritional Foods Association. We stand behind our product and offer a 100% Money Back Guarantee.

References
1. McCormick DB. Vitamin B6. In: Bowman BA, Russell RM, eds. Present Knowledge in Nutrition. Vol. I.
    Washington, D.C.: International Life Sciences Institute; 2006:269-277.
2. Leklem JE. Vitamin B6. In: Machlin L, ed. Handbook of Vitamins. New York: Marcel Decker Inc; 1991:341-378.
3. Dakshinamurti S, Dakshinamurti K. Vitamin B6. In: Zempleni J, Rucker RB, McCormick DB, Suttie JW, eds.
    Handbook of Vitamins. 4th ed. New York: CRC Press (Taylor & Fracis Group); 2007:315-359.
4. Leklem JE. Vitamin B6. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease.
    9th ed. Baltimore: Williams & Wilkins; 1999:413-422.
5. Mackey A, Davis S, Gregory J. Vitamin B6. In: Shils M, Shike M, Ross A, Caballero B, Cousins R, eds. Modern
    Nutrition in Health and Disease. 10th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2005.Meydani SN,
    Ribaya-Mercado JD, Russell RM, Sahyoun N, Morrow FD, Gershoff SN. Vitamin B-6 deficiency impairs
    interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr. 1991;53(5):1275-1280.
6. Bryan J, Calvaresi E, Hughes D. Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects
    memory performance but not mood in women of various ages. J Nutr. 2002;132(6):1345-1356.
7. Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin
    B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press;
    1998.
8. Deijen JB, van der Beek EJ, Orlebeke JF, van den Berg H. Vitamin B-6 supplementation in elderly men: effects
    on mood, memory, performance and mental effort. Psychopharmacology (Berl). 1992;109(4):489-496.