Thiamine (Vitamin B1)

Thiamine is a water-soluble member of the Vitamin-B Complex,[1] and was one of the first organic compounds to be recognized as a vitamin.[2] It has a key role in the metabolism of energy in all cells.

Thiamin pyrophosphate (TPP) is a required coenzyme for a small number of very important enzymes. The thiamine–dependent enzyme transketolase is an important enzyme in the breakdown of glucose through a biochemical pathway called the pentose phosphate pathway.[3]

One of the most important intermediates of this pathway is in the synthesis of high-energy ATP. It is also required for the synthesis of the nucleic acids, DNA and RNA, and the niacin-containing coenzyme NADPH, which is essential for a number of biosynthetic reactions.[1,4]

ATP is often called the "molecular unit of currency" of intracellular energy transfer.[5] ATP transports chemical energy within cells for metabolism. ATP is the main energy source for the majority of cellular functions. This includes the synthesis of macromolecules, including DNA and RNA, and proteins. ATP is continuously recycled in organisms: the human body turns over its own body weight in ATP each day.[6]

The European Food Safety authority was asked to deliver an opinion on the scientific substantiation of a health claim related to thiamine and carbohydrate and energy-yielding metabolism. The Panel summarized, “vitamin B1 plays an important role in the carbohydrate and energy metabolism of food”.[7]

Each serving of Elebra contains Thiamine, and is manufactured in the USA at a cGMP facility that has an "A" rating (the highest possible) from the National Nutritional Foods Association. We stand behind our product and offer a 100% Money Back Guarantee.

References
1. Tanphaichitr V. Thiamin. In: Shils M, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease.
    9th ed. Baltimore: Williams & Wilkins; 1999:381-389.
2. Rindi G. Thiamin. In: Ziegler EE, Filer LJ, eds. Present Knowledge in Nutrition. 7th ed. Washington D.C.: ILSI
    Press; 1996:160-166.
3. Martin, PR, Singleton, CK, Hiller-Sturmhofel, S (2003). "The role of thiamine deficiency in alcoholic brain
    disease". Alcohol Research and Health 27 (2): 134–142.
4. Brody T. Nutritional Biochemistry. 2nd ed. San Diego: Academic Press; 1999.
5. Knowles JR (1980). "Enzyme-catalyzed phosphoryl transfer reactions". Annu. Rev. Biochem. 49: 877–919.
6. Törnroth-Horsefield S, Neutze R (December 2008). "Opening and closing the metabolite gate". Proc. Natl.
    Acad. Sci. U.S.A. 105 (50): 19565–6.
7. Scientific Opinion on the substantiation of a health claim related to thiamine and carbohydrate and energy-
    yielding metabolism pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal 2010; 8(7):1690.