Acetyl L-Carnitine

It has been claimed Acetyl-L-Carnitine is superior to L-Carnitine in terms of bioavailability.[1]

Acetyl-L-Carnitine has the ability to cross the blood-brain barrier and act as an antioxidant.[2]

Acetyl-L-Carnitine also preserves the level of brain-derived neutrophic factor,[3] which helps support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses.[4],[5]

Acetyl-L-Carnitine also helps your brain metabolize fat.[6]

Acetyl-L-Carnitine supplementation not only stops the progression of the inflammation and free radical damage it actually helps reverse the problem.[7]

Acetyl-L-Carnitine is one of a number of nutrients that has an energetic effect on your brain cells.[8]

Another study showed Acetyl-L-Carnitine restored brain energetics resulting in less free radicals and less lipofusion formation (age spots).[9]

Of particular importance is the ability of Acetyl-L-Carnitine to protect the mitochondria—the intracellular powerhouses.[10]

Acetyl-L-Carnitine helps to preserve the integrity of mitochondria,[11] which are your cell’s car engines. This is a direct anti-aging function on their integrity, facilitating a cell’s ability to make energy. Individuals with chronic fatigue are consistently low in Acetyl-L-Carnitine.[12]

In the face of stress, Acetyl-L-Carnitine helps to maintain your brain’s energy supply, meaning that it noticeably helps you to cope with stress in a more efficient manner.[13]

The combination of Acetyl-L-Carnitine and R-aplha lipoic acid has been shown to turn on metabolism within your stored fat,[14] in turn providing energy to help break down fat to use as fuel. Acetyl-L-Carnitine turns on specific genes that help do this.

A study from Berkeley showed Acetyl-L-Carnitine supplementation significantly reverses the age-associated decline of mitochondrial membrane function.[15] A similar second study, also from Berkeley, again concluded the ability of Acetyl-L-Carnitine to reverse age-related mitochondrial decay.[16]

Acetyl-L-Carnitine has been shown to increase the output of neurotransmitters serotonin and dopamine.[15]

Each serving of Elebra contains Acetyl-L-Carnitine, and is manufactured in the USA at a cGMP facility that has an "A" rating (the highest possible) from the National Nutritional Foods Association. We stand behind our product and will gladly refund your money if you are not satisfied for any reason.

References
1. Jane Higdon, Ph.D. (October 2002). L-Carnitine. Linus Pauling Institute at Oregon State University.
2. Barhwal K, Hota SK, Jain V, Prasad D, Singh SB, Ilavazhagan G (June 2009). "Acetyl-l-carnitine (ALCAR)
    prevents hypobaric hypoxia-induced spatial memory impairment through extracellular related kinase-mediated
    nuclear factor erythroid 2-related factor 2 phosphorylation". Neuroscience 161 (2): 501–14.
    doi:10.1016/j.neuroscience.2009.02.086. PMID 19318118
3. Bigini P, Larini S, Pasquali C, Muzio V, Mennini T. Acetyl-L-carnitine shows neuroprotective and neurotrophic
    activity in primary culture of rat embryo motoneurons. Neurosci Lett 2002 Sep 6;329(3):334-8
4. Acheson A, Conover JC, Fandl JP, DeChiara TM, Russell M, Thadani A, Squinto SP, Yancopoulos GD, Lindsay
    RM (March 1995). "A BDNF autocrine loop in adult sensory neurons prevents cell death". Nature 374 (6521):
    450–3. doi:10.1038/374450a0.PMID 7700353
5. Huang EJ, Reichardt LF (2001). "Neurotrophins: Roles in Neuronal Development and Function". Annu. Rev.
    Neurosci. 24: 677–736.doi:10.1146/annurev.neuro.24.1.677. PMC 2758233. PMID 11520916
6. Tanaka Y, Sasaki R, Fukui F, Waki H, Kawabata T, Okazaki M, Hasegawa K, Ando S. Acetyl-L-carnitine
    supplementation restores decreased tissue carnitine levels and impaired lipid metabolisms in aged rats. J Lipid
    Res. 2004 January
7. Sharman EH, Vaziri ND, Ni Z, Sharman KG, Bondy SC. Reversal of biochemical and behavioral parameters of
    brain aging by melatonin and acetyl L-carnitine. Brain Res. 2002 December 13; 957(2): 223-30.
8. Kidd PM. Neurodegeneration from mitochondrial insufficiency: nutrients, stem cells, growth factors, and
    prospects for brain rebuilding using integrative management. Altern Med Rev. 2005 December 10(4):268-93.
    University of California, Berkeley, USA.
9. Kaur J, Sharma D, Singh R. Acetyl-L-carnitine enhances Na(+), K(+)-ATPase glutathione-S-transferase and
    multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions.
    Neurosci Lett. 2001 March ; 301(1): 1-4.
10. Gadaleta MN, Cormio A, Pesce V, Lezza AM, Cantatore P. Aging and mitochondria. Biochimie
    1998;80(10):863-70.
11. Aliev G, Liu J, Shenk JC, Fischbach K, Pacheco GJ, Chen SG, Obrenovich ME, Ward WF, Richardson AG,
    Smith MA, Gasimov E, Perry G, Ames BN. Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine
    and lipoic acid to aged rats. J Cell Mol Med. 2008 March Epub ahead of print.
12. Kuratsune H, Yamaguti K, Lindh G, Evengard B, Hagberg G, Matsumura K, Iwase M, Onoe H, Takahashi M,
    Machii T, Kanakura Y, Kitani T, Langstrom B, Watanabe Y. Brain regions involved in fatigue sensation: reduced
    acetylcarnitine uptake into the brain. Neuroimage. 2002 November 17(3): 1256-65.
13. Dhitavat S, Ortiz D, Shea TB, Rivera ER. Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: roles
    of oxidative buffering and ATP levels. Neurochem Res. 2002 June 27(6): 501-5.
14. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, Packer L, Cotman CW, Liu J. R-alpha-lipoic acid and
    acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes.
    Diabetologia. 2008 January 51(1):165-74.
15. Hagen TM, Ingersoll RT, Wehr CM, Lykkesfelt J, Vinarsky V, Bartholomew JC, Song MH, Ames BN,
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
    Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc Natl
    Acad Sci USA (United States) August 4, 1998, 95 (16) p.9562-6.
16. Hagen TM, Wehr CM, Ames Bn. Department of Molecular and Cell Biology, University of California at Berkeley
    94720, USA. Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and
    N-tert-butyl-alpha-phenyl-nitrone. Ann N Y Acad Sci (United States) November 20, 1998, 854 p.214-23.
17. Tolu P, Masi F, Leggio B, Scheggi S, Tagliamonte A, De Montis MG, Gambarana C. Effects of long-term
    acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and
    protection toward acute stress exposure. Neuropsychopharmacology. 2002 September 27(3): 410-20.